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Target
Matrix protein 2 [1-96]
Ligand
BDBM50079999
Substrate
n/a
Meas. Tech.
ChEMBL_1471014 (CHEMBL3420061)
IC50
3300±n/a nM
Citation
 Rey-Carrizo, M; Gazzarrini, S; Llabrés, S; Frigolé-Vivas, M; Juárez-Jiménez, J; Font-Bardia, M; Naesens, L; Moroni, A; Luque, FJ; Vázquez, S New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode. Eur J Med Chem 96:318-29 (2015) [PubMed]  Article 
Target
Name:
Matrix protein 2 [1-96]
Synonyms:
M | M2_I72A2 | Matrix protein 2
Type:
PROTEIN
Mol. Mass.:
11051.96
Organism:
Influenza A virus
Description:
ChEMBL_1453980
Residue:
96
Sequence:
MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIEL
  
Inhibitor
Name:
BDBM50079999
Synonyms:
CHEMBL3415951
Type:
Small organic molecule
Emp. Form.:
C11H15N
Mol. Mass.:
161.2435
SMILES:
[H][C@@]12C3CC4[C@]1([H])[C@@]1([H])CNC[C@@]1([H])[C@@]4([H])[C@@]23[H] |r,TLB:2:1:4:12.7,2:16:4:12.7,11:12:4:1.16,THB:3:4:1.16:12.7,12:14:5:2.3,7:5:2.3:16.14,9:7:4:1.16|
Structure:
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