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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50084409
Substrate
n/a
Meas. Tech.
ChEMBL_1477653 (CHEMBL3428032)
IC50
11500±n/a nM
Citation
 Iqbal, Z; Hameed, S; Ali, S; Tehseen, Y; Shahid, M; Iqbal, J Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5'-imidazolidine]-2',4'-diones. Eur J Med Chem 98:127-38 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50084409
Synonyms:
CHEMBL3426179
Type:
Small organic molecule
Emp. Form.:
C21H13BrN2O4S
Mol. Mass.:
469.308
SMILES:
Brc1ccc(cc1)S(=O)(=O)N1C(=O)NC(=O)C11c2ccccc2-c2ccccc12
Structure:
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