Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50084416
Substrate
n/a
Meas. Tech.
ChEMBL_1477654 (CHEMBL3428033)
IC50
11300±n/a nM
Citation
 Iqbal, Z; Hameed, S; Ali, S; Tehseen, Y; Shahid, M; Iqbal, J Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5'-imidazolidine]-2',4'-diones. Eur J Med Chem 98:127-38 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50084416
Synonyms:
CHEMBL3426176
Type:
Small organic molecule
Emp. Form.:
C29H16N2O6S
Mol. Mass.:
520.512
SMILES:
O=C1NC2(C(=O)N1S(=O)(=O)c1ccc3C(=O)c4ccccc4C(=O)c3c1)c1ccccc1-c1ccccc21
Structure:
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