Reaction Details Report a problem with these data
Target
UDP-glucuronosyltransferase 1A10
Ligand
BDBM50358252
Substrate
n/a
Meas. Tech.
ChEMBL_1493837 (CHEMBL3527845)
Ki
235000±n/a nM
Citation
 Shiraga, T; Yajima, K; Suzuki, K; Suzuki, K; Hashimoto, T; Iwatsubo, T; Miyashita, A; Usui, T Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine. Drug Metab Dispos 40:276-82 (2012) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A10
Synonyms:
GNT1 | UD110_HUMAN | UDP-glucuronosyltransferase 1-10 | UDP-glucuronosyltransferase 1-J | UDP-glucuronosyltransferase 1A10 | UDPGT 1-10 | UGT-1J | UGT1 | UGT1*10 | UGT1-10 | UGT1.10 | UGT1A10 | UGT1J
Type:
PROTEIN
Mol. Mass.:
59817.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1491709
Residue:
530
Sequence:
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50358252
Synonyms:
CHEMBL1922235
Type:
Small organic molecule
Emp. Form.:
C27H30N4O4
Mol. Mass.:
474.5515
SMILES:
COc1ccc(cc1)C(=O)Nc1cccc(O)c1NC(=O)c1ccc(cc1)N1CCCN(C)CC1
Structure:
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