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Target
Potassium voltage-gated channel subfamily B member 1
Ligand
BDBM50088573
Substrate
n/a
Meas. Tech.
ChEMBL_1496410 (CHEMBL3580176)
IC50
590±n/a nM
Citation
 Kim, H; Yang, I; Ryu, SY; Won, DH; Giri, AG; Wang, W; Choi, H; Chin, J; Hahn, D; Kim, E; Han, C; Lee, J; Nam, SJ; Ho, WK; Kang, H Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015. J Nat Prod 78:363-7 (2015) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily B member 1
Synonyms:
DRK1 | Delayed rectifier potassium channel 1 | KCNB1 | KCNB1_HUMAN | Potassium voltage-gated channel subfamily B member 1 | Voltage-gated potassium channel subunit Kv2.1 | Voltage-gated potassium channel subunit Kv2.1 (Kv2.1) | h-DRK1
Type:
Protein
Mol. Mass.:
95890.66
Organism:
Homo sapiens (Human)
Description:
Q14721
Residue:
858
Sequence:
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTRDQSI
  
Inhibitor
Name:
BDBM50088573
Synonyms:
CHEMBL3577208
Type:
Small organic molecule
Emp. Form.:
C36H34O10
Mol. Mass.:
626.6492
SMILES:
COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1C1=C(c2c(C1=O)c(OC)c(C)cc2O)c1c(OC)cccc1OC |t:24|
Structure:
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