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Target
Histamine H3 receptor
Ligand
BDBM50089368
Substrate
n/a
Meas. Tech.
ChEMBL_1496464 (CHEMBL3578410)
Ki
2.0±n/a nM
Citation
 Letavic, MA; Aluisio, L; Apodaca, R; Bajpai, M; Barbier, AJ; Bonneville, A; Bonaventure, P; Carruthers, NI; Dugovic, C; Fraser, IC; Kramer, ML; Lord, B; Lovenberg, TW; Li, LY; Ly, KS; Mcallister, H; Mani, NS; Morton, KL; Ndifor, A; Nepomuceno, SD; Pandit, CR; Sands, SB; Shah, CR; Shelton, JE; Snook, SS; Swanson, DM; Xiao, W Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development. ACS Med Chem Lett 6:450-4 (2015) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50089368
Synonyms:
CHEMBL3577960
Type:
Small organic molecule
Emp. Form.:
C20H28FN3O
Mol. Mass.:
345.4542
SMILES:
FC1CCN(Cc2ccc(cc2)C(=O)N2CCN(CC2)C2CC2)CC1
Structure:
Search PDB for entries with ligand similarity: