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Target
Tyrosine-protein kinase FRK
Ligand
BDBM50097393
Substrate
n/a
Meas. Tech.
ChEMBL_1501941 (CHEMBL3588281)
IC50
41±n/a nM
Citation
 Smith, CR; Dougan, DR; Komandla, M; Kanouni, T; Knight, B; Lawson, JD; Sabat, M; Taylor, ER; Vu, P; Wyrick, C Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J Med Chem 58:5437-44 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase FRK
Synonyms:
FRK | FRK_HUMAN | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | RAK | SRC | Tyrosine Kinase FRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
58254.41
Organism:
Homo sapiens (Human)
Description:
P42685
Residue:
505
Sequence:
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
  
Inhibitor
Name:
BDBM50097393
Synonyms:
CHEMBL3586447
Type:
Small organic molecule
Emp. Form.:
C17H14N6O
Mol. Mass.:
318.3327
SMILES:
Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(nnc12)C(N)=O
Structure:
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