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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50097864
Substrate
n/a
Meas. Tech.
ChEMBL_1502245 (CHEMBL3591181)
IC50
300±n/a nM
Citation
 Falke, H; Chaikuad, A; Becker, A; Loaëc, N; Lozach, O; Abu Jhaisha, S; Becker, W; Jones, PG; Preu, L; Baumann, K; Knapp, S; Meijer, L; Kunick, C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem 58:3131-43 (2015) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty
Type:
PROTEIN
Mol. Mass.:
57124.52
Organism:
Mus musculus
Description:
ChEMBL_1502245
Residue:
483
Sequence:
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
  
Inhibitor
Name:
BDBM50097864
Synonyms:
CHEMBL3589675
Type:
Small organic molecule
Emp. Form.:
C23H15ClN2O3
Mol. Mass.:
402.83
SMILES:
COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1
Structure:
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