Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50378008
Substrate
n/a
Meas. Tech.
ChEMBL_1502288 (CHEMBL3591367)
Ki
0.920000±n/a nM
Citation
 Keck, TM; John, WS; Czoty, PW; Nader, MA; Newman, AH Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. J Med Chem 58:5361-80 (2015) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50378008
Synonyms:
CHEMBL1627314
Type:
Small organic molecule
Emp. Form.:
C24H28Cl2N4O3
Mol. Mass.:
491.41
SMILES:
COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl
Structure:
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