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Target
Subtilisin-like protease 1
Ligand
BDBM50100887
Substrate
n/a
Meas. Tech.
ChEMBL_1456858 (CHEMBL3367591)
Ki
6000±n/a nM
Citation
 Kher, SS; Penzo, M; Fulle, S; Finn, PW; Blackman, MJ; Jirgensons, A Substrate derived peptidica-ketoamides as inhibitors of the malarial protease PfSUB1. Bioorg Med Chem Lett 24:4486-9 (2014) [PubMed]  Article 
Target
Name:
Subtilisin-like protease 1
Synonyms:
SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1
Type:
PROTEIN
Mol. Mass.:
77866.88
Organism:
Plasmodium falciparum
Description:
ChEMBL_830092
Residue:
690
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
  
Inhibitor
Name:
BDBM50100887
Synonyms:
CHEMBL3325857
Type:
Small organic molecule
Emp. Form.:
C26H22N4O2
Mol. Mass.:
422.4785
SMILES:
COc1ccc(Nc2cc(C)c3cc(NC(=O)c4cc5ccccc5[nH]4)ccc3n2)cc1
Structure:
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