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Target
Subtilisin-like protease 1
Ligand
BDBM50100892
Substrate
n/a
Meas. Tech.
ChEMBL_1456858 (CHEMBL3367591)
IC50
7000±n/a nM
Citation
 Kher, SS; Penzo, M; Fulle, S; Finn, PW; Blackman, MJ; Jirgensons, A Substrate derived peptidica-ketoamides as inhibitors of the malarial protease PfSUB1. Bioorg Med Chem Lett 24:4486-9 (2014) [PubMed]  Article 
Target
Name:
Subtilisin-like protease 1
Synonyms:
SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1
Type:
PROTEIN
Mol. Mass.:
77866.88
Organism:
Plasmodium falciparum
Description:
ChEMBL_830092
Residue:
690
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
  
Inhibitor
Name:
BDBM50100892
Synonyms:
CHEMBL3354605
Type:
Small organic molecule
Emp. Form.:
C30H53ClN8O11
Mol. Mass.:
737.242
SMILES:
Cl.CC[C@@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NC(CCC(N)=O)C(=O)C(=O)NCCC(O)=O |r|
Structure:
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