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Target
DNA-3-methyladenine glycosylase
Ligand
BDBM23223
Substrate
n/a
Meas. Tech.
ChEMBL_1463504 (CHEMBL3398686)
IC50
3000±n/a nM
Citation
 Dixon, M; Woodrick, J; Gupta, S; Karmahapatra, SK; Devito, S; Vasudevan, S; Dakshanamurthy, S; Adhikari, S; Yenugonda, VM; Roy, R Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease. Bioorg Med Chem 23:1102-11 (2015) [PubMed]  Article 
Target
Name:
DNA-3-methyladenine glycosylase
Synonyms:
3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | ADPG | N-methylpurine-DNA glycosylase | 3MG_HUMAN | MPG | AAG | ANPG | MID1
Type:
PROTEIN
Mol. Mass.:
32883.92
Organism:
Human
Description:
ChEMBL_109564
Residue:
298
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
  
Inhibitor
Name:
BDBM23223
Synonyms:
Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde | Pogosin | CHEMBL51483 | cid_3503 | Gossypol | Gossypol (C9) | US9115061, Gossypol
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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