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Target
Histone deacetylase 1
Ligand
BDBM50108184
Substrate
n/a
Meas. Tech.
ChEMBL_1508563 (CHEMBL3602646)
IC50
66±n/a nM
Citation
 Yang, W; Li, L; Wang, Y; Wu, X; Li, T; Yang, N; Su, M; Sheng, L; Zheng, M; Zang, Y; Li, J; Liu, H Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors. Bioorg Med Chem 23:5881-90 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50108184
Synonyms:
CHEMBL3601774
Type:
Small organic molecule
Emp. Form.:
C22H31N3O4
Mol. Mass.:
401.4992
SMILES:
CC(C)CCn1ccc2ccc(NC(=O)CCCCCCC(=O)NO)cc2c1=O
Structure:
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