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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50108929
Substrate
n/a
Meas. Tech.
ChEMBL_1507045 (CHEMBL3599999)
IC50
3700±n/a nM
Citation
 Lee, CC; Liu, FL; Chen, CL; Chen, TC; Liu, FC; Ahmed Ali, AA; Chang, DM; Huang, HS Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones. Bioorg Med Chem 23:4522-32 (2015) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | Opgl | Osteoclast differentiation factor | Osteoprotegerin ligand | Rankl | Receptor activator of nuclear factor kappa-B ligand | TNF-related activation-induced cytokine | TNF11_MOUSE | Tnfsf11 | Trance | Tumor necrosis factor ligand superfamily member 11, membrane form | Tumor necrosis factor ligand superfamily member 11, soluble form
Type:
PROTEIN
Mol. Mass.:
35008.20
Organism:
Mus musculus
Description:
ChEMBL_109846
Residue:
316
Sequence:
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
  
Inhibitor
Name:
BDBM50108929
Synonyms:
CHEMBL3596956
Type:
Small organic molecule
Emp. Form.:
C22H11F2NO3
Mol. Mass.:
375.3244
SMILES:
Fc1ccc(c(F)c1)-c1ccc2oc(=O)n(-c3cccc(c3)C#C)c(=O)c2c1
Structure:
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