Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50108930
Substrate
n/a
Meas. Tech.
ChEMBL_1507045 (CHEMBL3599999)
IC50
10600±n/a nM
Citation
 Lee, CC; Liu, FL; Chen, CL; Chen, TC; Liu, FC; Ahmed Ali, AA; Chang, DM; Huang, HS Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones. Bioorg Med Chem 23:4522-32 (2015) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | Opgl | Osteoclast differentiation factor | Osteoprotegerin ligand | Rankl | Receptor activator of nuclear factor kappa-B ligand | TNF-related activation-induced cytokine | TNF11_MOUSE | Tnfsf11 | Trance | Tumor necrosis factor ligand superfamily member 11, membrane form | Tumor necrosis factor ligand superfamily member 11, soluble form
Type:
PROTEIN
Mol. Mass.:
35008.20
Organism:
Mus musculus
Description:
ChEMBL_109846
Residue:
316
Sequence:
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
  
Inhibitor
Name:
BDBM50108930
Synonyms:
CHEMBL3335186
Type:
Small organic molecule
Emp. Form.:
C14H7ClFNO3
Mol. Mass.:
291.662
SMILES:
Fc1cc(Cl)ccc1-n1c(=O)oc2ccccc2c1=O |(22.73,-16.85,;22.73,-15.31,;24.06,-14.54,;24.05,-13,;25.38,-12.22,;22.71,-12.23,;21.38,-13.01,;21.4,-14.54,;20.07,-15.31,;20.07,-16.87,;21.4,-17.64,;18.74,-17.64,;17.4,-16.87,;16.07,-17.64,;14.73,-16.87,;14.74,-15.33,;16.06,-14.56,;17.4,-15.32,;18.73,-14.55,;18.73,-13.01,)|
Structure:
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