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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50109039
Substrate
n/a
Meas. Tech.
ChEMBL_1508579 (CHEMBL3602662)
IC50
>50000±n/a nM
Citation
 Meena, CL; Thakur, A; Nandekar, PP; Sangamwar, AT; Sharma, SS; Jain, R Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice. Bioorg Med Chem 23:5641-53 (2015) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44568.52
Organism:
MOUSE
Description:
thyrotropin-releasing hormone R1 TRHR MOUSE::P21761
Residue:
393
Sequence:
MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
  
Inhibitor
Name:
BDBM50109039
Synonyms:
CHEMBL3600454
Type:
Small organic molecule
Emp. Form.:
C17H19Br2N7O3
Mol. Mass.:
529.186
SMILES:
Cc1cnc(cn1)C(=O)N[C@@H](Cc1nc(Br)[nH]c1Br)C(=O)N1CCC[C@H]1C(N)=O |r|
Structure:
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