Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 9
Ligand
BDBM50112357
Substrate
n/a
Meas. Tech.
ChEMBL_1513403 (CHEMBL3611558)
IC50
>50000±n/a nM
Citation
 He, R; Yu, ZH; Zhang, RY; Wu, L; Gunawan, AM; Lane, BS; Shim, JS; Zeng, LF; He, Y; Chen, L; Wells, CD; Liu, JO; Zhang, ZY Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett 6:782-6 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9
Synonyms:
3.1.3.48 | PTN9_HUMAN | PTP-MEG2 | PTPN9 | PTPase MEG2 | Protein-tyrosine phosphatase MEG2 | Protein-tyrosine phosphatase MEG2 (PTP-Meg2) | Tyrosine-protein phosphatase non-receptor type 9
Type:
n/a
Mol. Mass.:
68030.33
Organism:
Homo sapiens (Human)
Description:
P43378
Residue:
593
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
  
Inhibitor
Name:
BDBM50112357
Synonyms:
CHEMBL3609375
Type:
Small organic molecule
Emp. Form.:
C25H25N3O6S
Mol. Mass.:
495.548
SMILES:
CC(C)c1ccc(NC(=O)C(=O)Nc2ccc(NC(=O)C(c3ccccc3)S(O)(=O)=O)cc2)cc1
Structure:
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