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Target
LIP1, secretory lipase (Family 3)
Ligand
BDBM50112885
Substrate
n/a
Meas. Tech.
ChEMBL_1512200 (CHEMBL3611482)
IC50
98340±n/a nM
Citation
 Guo, S; Huang, W; Zhang, J; Wang, Y Novel inhibitor against Malassezia globosa LIP1 (SMG1), a potential anti-dandruff target. Bioorg Med Chem Lett 25:3464-7 (2015) [PubMed]  Article 
Target
Name:
LIP1, secretory lipase (Family 3)
Synonyms:
LIP1, secretory lipase (Family 3)
Type:
PROTEIN
Mol. Mass.:
33701.74
Organism:
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)
Description:
ChEMBL_109860
Residue:
304
Sequence:
MLFSRFVLLAFGSVAAVSASSIYARGRGGSSTDQPVANPYNTKEISLAAGLVQQTYCDSTENGLKIGDSELLYTMGEGYARQRVNIYHSPSLGIAVAIEGTNLFSLNSDLHDAKFWQEDPNERYIQYYPKGTKLMHGFQQAYNDLMDDIFTAVKKYKKEKNEKRVTVIGHSLGAAMGLLCAMDIELRMDGGLYKTYLFGLPRLGNPTFASFVDQKIGDKFHSIINGRDWVPTVPPRALGYQHPSDYVWIYPGNSTSAKLYPGQENVHGILTVAREFNFDDHQGIYFHTQIGAVMGECPAQVGAH
  
Inhibitor
Name:
BDBM50112885
Synonyms:
CHEMBL3609532
Type:
Small organic molecule
Emp. Form.:
C14H11NO3S
Mol. Mass.:
273.307
SMILES:
OC(=O)c1ccc(=S)n(CC(=O)c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: