Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-14
Ligand
BDBM50119285
Substrate
n/a
Meas. Tech.
ChEMBL_1518241 (CHEMBL3620108)
IC50
41±n/a nM
Citation
 Nuti, E; Cantelmo, AR; Gallo, C; Bruno, A; Bassani, B; Camodeca, C; Tuccinardi, T; Vera, L; Orlandini, E; Nencetti, S; Stura, EA; Martinelli, A; Dive, V; Albini, A; Rossello, A N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity. J Med Chem 58:7224-40 (2015) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-14
Synonyms:
MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
Type:
Protein
Mol. Mass.:
65900.19
Organism:
Homo sapiens (Human)
Description:
P50281
Residue:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
  
Inhibitor
Name:
BDBM50119285
Synonyms:
CHEMBL3617402
Type:
Small organic molecule
Emp. Form.:
C21H27N3O6S
Mol. Mass.:
449.521
SMILES:
CC(C)ON([C@H](CCNC(C)=O)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: