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Target
Potassium voltage-gated channel subfamily KQT member 4
Ligand
BDBM50121051
Substrate
n/a
Meas. Tech.
ChEMBL_1520985 (CHEMBL3624289)
EC50
625±n/a nM
Citation
 Davoren, JE; Claffey, MM; Snow, SL; Reese, MR; Arora, G; Butler, CR; Boscoe, BP; Chenard, L; DeNinno, SL; Drozda, SE; Duplantier, AJ; Moine, L; Rogers, BN; Rong, S; Schuyten, K; Wright, AS; Zhang, L; Serpa, KA; Weber, ML; Stolyar, P; Whisman, TL; Baker, K; Tse, K; Clark, AJ; Rong, H; Mather, RJ; Lowe, JA Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett 25:4941-4 (2015) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 4
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:
PROTEIN
Mol. Mass.:
77131.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1520985
Residue:
695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
  
Inhibitor
Name:
BDBM50121051
Synonyms:
CHEMBL3621437
Type:
Small organic molecule
Emp. Form.:
C18H30N4O4
Mol. Mass.:
366.4552
SMILES:
COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Structure:
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