Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50121219
Substrate
n/a
Meas. Tech.
ChEMBL_1522006 (CHEMBL3627113)
EC50
50±n/a nM
Citation
 Nagahara, T; Saitoh, T; Kutsumura, N; Irukayama-Tomobe, Y; Ogawa, Y; Kuroda, D; Gouda, H; Kumagai, H; Fujii, H; Yanagisawa, M; Nagase, H Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem 58:7931-7 (2015) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50121219
Synonyms:
CHEMBL3622422
Type:
Small organic molecule
Emp. Form.:
C32H34N4O6S
Mol. Mass.:
602.701
SMILES:
COc1ccccc1C(=O)NCCNc1cccc(NS(=O)(=O)c2cc(ccc2OC)-c2cccc(c2)C(=O)N(C)C)c1
Structure:
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