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Target
Ornithine aminotransferase, mitochondrial
Ligand
BDBM50121376
Substrate
n/a
Meas. Tech.
ChEMBL_1522254 (CHEMBL3626483)
Ki
2.1±n/a nM
Citation
 Zigmond, E; Ben Ya'acov, A; Lee, H; Lichtenstein, Y; Shalev, Z; Smith, Y; Zolotarov, L; Ziv, E; Kalman, R; Le, HV; Lu, H; Silverman, RB; Ilan, Y Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. ACS Med Chem Lett 6:840-4 (2015) [PubMed]  Article 
Target
Name:
Ornithine aminotransferase, mitochondrial
Synonyms:
OAT | OAT_HUMAN | Ornithine aminotransferase, hepatic form | Ornithine aminotransferase, mitochondrial | Ornithine aminotransferase, renal form | Ornithine delta-aminotransferase | Ornithine--oxo-acid aminotransferase
Type:
PROTEIN
Mol. Mass.:
48537.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102740
Residue:
439
Sequence:
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
  
Inhibitor
Name:
BDBM50121376
Synonyms:
GABACULINE
Type:
Small organic molecule
Emp. Form.:
C7H11NO2
Mol. Mass.:
141.1677
SMILES:
N[C@@H]1CCCC(=C1)C(O)=O |r,c:5|
Structure:
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