Reaction Details Report a problem with these data
Target
Aromatase
Ligand
BDBM50097366
Substrate
n/a
Meas. Tech.
ChEMBL_1520473 (CHEMBL3624602)
IC50
40±n/a nM
Citation
 Ahmad, I; Shagufta, na Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. Eur J Med Chem 102:375-86 (2015) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50097366
Synonyms:
4-((1H-imidazol-1-yl)methyl)-1-nitro-4aH-xanthen-9(9aH)-one | 4-((1H-imidazol-1-yl)methyl)-1-nitro-9H-xanthen-9-one | 4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one | CHEMBL159073
Type:
Small organic molecule
Emp. Form.:
C17H11N3O4
Mol. Mass.:
321.2869
SMILES:
[O-][N+](=O)c1ccc(Cn2ccnc2)c2oc3ccccc3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: