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Target
Aromatase
Ligand
BDBM50009605
Substrate
n/a
Meas. Tech.
ChEMBL_1520468 (CHEMBL3624597)
IC50
4600±n/a nM
Citation
 Ahmad, I; Shagufta, na Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. Eur J Med Chem 102:375-86 (2015) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50009605
Synonyms:
2-(pyridin-4-ylmethylene)-3,4-dihydronaphthalen-1(2H)-one | 2-Pyridin-4-ylmethylene-3,4-dihydro-2H-naphthalen-1-one | 2-[1-Pyridin-4-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one | CHEMBL90585
Type:
Small organic molecule
Emp. Form.:
C16H13NO
Mol. Mass.:
235.2805
SMILES:
O=C1\C(CCc2ccccc12)=C\c1ccncc1
Structure:
Search PDB for entries with ligand similarity: