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Target
Kallikrein-4
Ligand
BDBM50125028
Substrate
n/a
Meas. Tech.
ChEMBL_1522075 (CHEMBL3627280)
Ki
20±n/a nM
Citation
 de Veer, SJ; Wang, CK; Harris, JM; Craik, DJ; Swedberg, JE Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library. J Med Chem 58:8257-68 (2015) [PubMed]  Article 
Target
Name:
Kallikrein-4
Synonyms:
EMSP1 | Enamel matrix serine proteinase 1 | KLK-L1 | KLK4 | KLK4_HUMAN | Kallikrein 4 | Kallikrein-4 | Kallikrein-like protein 1 | PRSS17 | PSTS | Prostase | Serine protease 17
Type:
PROTEIN
Mol. Mass.:
27022.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_595923
Residue:
254
Sequence:
MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS
  
Inhibitor
Name:
BDBM50125028
Synonyms:
CHEMBL3623791
Type:
Small organic molecule
Emp. Form.:
C69H105N21O17S2
Mol. Mass.:
1564.833
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)CNC(=O)[C@H](CC(N)=O)NC2=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@@]2([H])C(=O)N2CCC[C@@]2([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1 |r|
Structure:
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