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Target
Folate receptor alpha
Ligand
BDBM50126174
Substrate
n/a
Meas. Tech.
ChEMBL_1523801 (CHEMBL3632252)
IC50
0.610000±n/a nM
Citation
 Wang, L; Wallace, A; Raghavan, S; Deis, SM; Wilson, MR; Yang, S; Polin, L; White, K; Kushner, J; Orr, S; George, C; O'Connor, C; Hou, Z; Mitchell-Ryan, S; Dann, CE; Matherly, LH; Gangjee, A 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem 58:6938-59 (2015) [PubMed]  Article 
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18 | FOLR1_HUMAN | FOLR1 | FOLR
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Human
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50126174
Synonyms:
CHEMBL3628346
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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