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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50205363
Substrate
n/a
Meas. Tech.
ChEMBL_1524687 (CHEMBL3631081)
Kd
247000±n/a nM
Citation
 Burdick, DJ; Wang, S; Heise, C; Pan, B; Drummond, J; Yin, J; Goeser, L; Magnuson, S; Blaney, J; Moffat, J; Wang, W; Chen, H Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg Med Chem Lett 25:4728-32 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50205363
Synonyms:
6-(benzylamino)purine | 6-BAP | 6-[(phenylmethyl)amino]-9H-purine | BAP | CHEMBL228862 | Cytokinin B | N(6)-(benzylamino)purine | N-benzyl-9H-purin-6-amine | N-benzyladenine | benzyladenine
Type:
Small organic molecule
Emp. Form.:
C12H11N5
Mol. Mass.:
225.2492
SMILES:
C(Nc1ncnc2nc[nH]c12)c1ccccc1
Structure:
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