Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50127857
Substrate
n/a
Meas. Tech.
ChEMBL_1522987 (CHEMBL3631163)
Ki
>10000±n/a nM
Citation
 Fu, H; Hou, X; Wang, L; Dun, Y; Yang, X; Fang, H Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors. Bioorg Med Chem Lett 25:5265-9 (2015) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50127857
Synonyms:
CHEMBL3628075
Type:
Small organic molecule
Emp. Form.:
C24H16FNO4S2
Mol. Mass.:
465.517
SMILES:
OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(F)cc3)cc2)cc1
Structure:
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