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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50128344
Substrate
n/a
Meas. Tech.
ChEMBL_1523722 (CHEMBL3631861)
IC50
4900±n/a nM
Citation
 Kang, JH; Ting, Z; Moon, MR; Sim, JS; Lee, JM; Doh, KE; Hong, S; Cui, M; Choi, S; Chang, HW; Park Choo, HY; Yim, M 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression. Bioorg Med Chem 23:7069-78 (2015) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase | LOX5_MOUSE
Type:
PROTEIN
Mol. Mass.:
77961.27
Organism:
Mus musculus
Description:
ChEMBL_675639
Residue:
674
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50128344
Synonyms:
CHEMBL3629177
Type:
Small organic molecule
Emp. Form.:
C26H27N5O5
Mol. Mass.:
489.5231
SMILES:
COc1ccc(Nc2nc3cc(NC(=O)CCCCOc4ccc(cc4)C(\N)=N\O)ccc3o2)cc1
Structure:
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