Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase VIM-2
Ligand
BDBM50442179
Substrate
n/a
Meas. Tech.
ChEMBL_1523080 (CHEMBL3631657)
Kd
333000±n/a nM
Citation
 Christopeit, T; Carlsen, TJ; Helland, R; Leiros, HK Discovery of Novel Inhibitor Scaffolds against the Metallo-ß-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening. J Med Chem 58:8671-82 (2015) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase VIM-2
Synonyms:
Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2)
Type:
Protein
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM50442179
Synonyms:
CHEMBL2441619
Type:
Small organic molecule
Emp. Form.:
C15H16F3N3
Mol. Mass.:
295.3028
SMILES:
Cc1ccc2nc(cc(N3CCNCC3)c2c1)C(F)(F)F
Structure:
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