Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50130929
Substrate
n/a
Meas. Tech.
ChEBML_1526060
IC50
>100000±n/a nM
Citation
 Yu, XR; Tang, Y; Wang, WJ; Ji, S; Ma, S; Zhong, L; Zhang, CH; Yang, J; Wu, XA; Fu, ZY; Li, LL; Yang, SY Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Bioorg Med Chem Lett 25:5449-53 (2015) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50130929
Synonyms:
CHEMBL3633189
Type:
Small organic molecule
Emp. Form.:
C18H14N8O2
Mol. Mass.:
374.3562
SMILES:
NC(=N)c1ccc(Nc2ncnc(Nc3ccc(cc3)C#N)c2[N+]([O-])=O)cc1
Structure:
Search PDB for entries with ligand similarity: