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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50133868
Substrate
n/a
Meas. Tech.
ChEMBL_1526517 (CHEMBL3635405)
IC50
5.0±n/a nM
Citation
 Ho, SY; Keller, TH The use of porcupine inhibitors to target Wnt-driven cancers. Bioorg Med Chem Lett 25:5472-6 (2015) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:
PROTEIN
Mol. Mass.:
52337.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103574
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50133868
Synonyms:
CHEMBL3633804
Type:
Small organic molecule
Emp. Form.:
C22H21N7O3
Mol. Mass.:
431.4472
SMILES:
Cn1c2nc3CC[C@@H](CC(=O)Nc4ccc(nn4)-c4ccccc4)n3c2c(=O)n(C)c1=O |r|
Structure:
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