Reaction Details Report a problem with these data
Target
Carbonic anhydrase, alpha family
Ligand
BDBM29278
Substrate
n/a
Meas. Tech.
ChEMBL_1543854 (CHEMBL3749744)
Ki
933±n/a nM
Citation
 Vullo, D; Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorg Med Chem Lett 26:401-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase, alpha family
Synonyms:
Carbonic anhydrase, alpha family
Type:
PROTEIN
Mol. Mass.:
35831.01
Organism:
Thiomicrospira crunogena (strain XCL-2)
Description:
ChEMBL_109899
Residue:
315
Sequence:
MKKRFSFIFIFLVALPLYSANNVAAPLIDLGAEAKKQAQKSAATQSAVPEKESATKVAEKQKEPEEKAKPEPKKPPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPDRNRANTVYEFY
  
Inhibitor
Name:
BDBM29278
Synonyms:
CHEMBL310671 | Garantose | SAC | Saccharimide | Saccharin
Type:
Small organic molecule
Emp. Form.:
C7H5NO3S
Mol. Mass.:
183.185
SMILES:
O=C1NS(=O)(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: