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Target
Telomeric repeat-binding factor 2-interacting protein 1
Ligand
BDBM50136331
Substrate
n/a
Meas. Tech.
ChEMBL_1547632 (CHEMBL3755502)
Kd
11±n/a nM
Citation
 Ran, X; Liu, L; Yang, CY; Lu, J; Chen, Y; Lei, M; Wang, S Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. J Med Chem 59:328-34 (2016) [PubMed]  Article 
Target
Name:
Telomeric repeat-binding factor 2-interacting protein 1
Synonyms:
DRIP5 | Dopamine receptor-interacting protein 5 | RAP1 | RAP1 homolog | Repressor/activator protein 1 homolog | TE2IP_HUMAN | TERF2-interacting telomeric protein 1 | TERF2IP | TRF2-interacting telomeric protein 1 | hRap1
Type:
PROTEIN
Mol. Mass.:
44229.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116704
Residue:
399
Sequence:
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
  
Inhibitor
Name:
BDBM50136331
Synonyms:
CHEMBL3752722
Type:
Small organic molecule
Emp. Form.:
C110H154N24O28S2
Mol. Mass.:
2324.674
SMILES:
n/a
Structure:
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