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Target
Vitamin D3 receptor
Ligand
BDBM50236238
Substrate
n/a
Meas. Tech.
ChEMBL_1553657 (CHEMBL3766237)
IC50
46700±n/a nM
Citation
 Teske, KA; Bogart, JW; Sanchez, LM; Yu, OB; Preston, JV; Cook, JM; Silvaggi, NR; Bikle, DD; Arnold, LA Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem 109:238-46 (2016) [PubMed]  Article 
Target
Name:
Vitamin D3 receptor
Synonyms:
1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN
Type:
Protein
Mol. Mass.:
48288.72
Organism:
Homo sapiens (Human)
Description:
P11473
Residue:
427
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
  
Inhibitor
Name:
BDBM50236238
Synonyms:
(3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alpha-hydroxy-5beta-cholan-24-oic acid | 3alpha-hydroxy-5beta-cholanic acid | 3alpha-hydroxy-5beta-cholanoic acid | 5beta-cholanic acid-3alpha-ol | CHEMBL1478 | LCA | cid_9903 | lithocholic acid
Type:
Small organic molecule
Emp. Form.:
C24H40O3
Mol. Mass.:
376.5726
SMILES:
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure:
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