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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM50144563
Substrate
n/a
Meas. Tech.
ChEMBL_1551505 (CHEMBL3762926)
EC50
7.0±n/a nM
Citation
 Han, Q; Pabba, PK; Barbosa, J; Mabon, R; Healy, JP; Gardyan, MW; Terranova, KM; Brommage, R; Thompson, AY; Schmidt, JM; Wilson, AG; Xu, X; Tarver, JE; Carson, KG 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett 26:1184-7 (2016) [PubMed]  Article 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM_MOUSE | Notum | Palmitoleoyl-protein carboxylesterase NOTUM
Type:
PROTEIN
Mol. Mass.:
56587.82
Organism:
Mus musculus
Description:
ChEMBL_116720
Residue:
503
Sequence:
MGGEVRVLLLLGLLHWVGGSEGRKTWRRRGQQPPQPPPPPPLPQRAEVEPGAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESKGSRRWLLFLEGGWYCFNRENCDSRYSTMRRLMSSKDWPHTRTGTGILSSQPEENPHWWNANMVFIPYCSSDVWSGASPKSDKNEYAFMGSLIIQEVVRELLGKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELLEELGYPSIQVRGLADSGWFLDNKQYRRSDCIDTINCAPTDAIRRGIRYWSGMVPERCQRQFKEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKDVQASFAPACLSHEIIIRSYWTDVQVKGTSLPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCPWPHCNPSCPTIRDQFTGQEMNVAQFLMHMGFDVQTVAQQQGMEPSKLLGMLSNGN
  
Inhibitor
Name:
BDBM50144563
Synonyms:
CHEMBL3758280
Type:
Small organic molecule
Emp. Form.:
C14H13NOS
Mol. Mass.:
243.324
SMILES:
CC1Cc2cc(sc2-c2ccccc12)C(N)=O
Structure:
Search PDB for entries with ligand similarity: