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Target
Quinolone resistance protein NorA
Ligand
BDBM50153279
Substrate
n/a
Meas. Tech.
ChEMBL_1562415 (CHEMBL3778151)
IC50
10600±n/a nM
Citation
 Lepri, S; Buonerba, F; Goracci, L; Velilla, I; Ruzziconi, R; Schindler, BD; Seo, SM; Kaatz, GW; Cruciani, G Indole Based Weapons to Fight Antibiotic Resistance: A Structure-Activity Relationship Study. J Med Chem 59:867-91 (2016) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50153279
Synonyms:
CHEMBL3775483
Type:
Small organic molecule
Emp. Form.:
C26H32N2O4
Mol. Mass.:
436.5433
SMILES:
CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCOCC3)cc12
Structure:
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