Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase tousled-like 1
Ligand
BDBM50154291
Substrate
n/a
Meas. Tech.
ChEMBL_1560702 (CHEMBL3778053)
IC50
<5000±n/a nM
Citation
 Shchekotikhin, AE; Dezhenkova, LG; Tsvetkov, VB; Luzikov, YN; Volodina, YL; Tatarskiy, VV; Kalinina, AA; Treshalin, MI; Treshalina, HM; Romanenko, VI; Kaluzhny, DN; Kubbutat, M; Schols, D; Pommier, Y; Shtil, AA; Preobrazhenskaya, MN Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. Eur J Med Chem 112:114-29 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase tousled-like 1
Synonyms:
KIAA0137 | Serine/threonine-protein kinase tousled-like 1 | TLK1 | TLK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86722.30
Organism:
Homo sapiens (Human)
Description:
gi_33636698
Residue:
766
Sequence:
MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
  
Inhibitor
Name:
BDBM50154291
Synonyms:
CHEMBL3775181
Type:
Small organic molecule
Emp. Form.:
C23H22N2O9S
Mol. Mass.:
502.494
SMILES:
CS(O)(=O)=O.Cc1oc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c2c1C(=O)N1CC[C@H](N)C1 |r|
Structure:
Search PDB for entries with ligand similarity: