Reaction Details Report a problem with these data
Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50179250
Substrate
n/a
Meas. Tech.
ChEMBL_1582564 (CHEMBL3816826)
IC50
5200±n/a nM
Citation
Kossmann, BR; Abdelmalak, M; Lopez, S; Tender, G; Yan, C; Pommier, Y; Marchand, C; Ivanov, I Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett 26:3232-3236 (2016) [PubMed] Article
More Info.:
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TRAF and TNF receptor-associated protein homolog | TYDP2_DANRE | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | si:dkey-218n20.5 | tdp2 | ttrap | ttrap | ttrapl
Type:
PROTEIN
Mol. Mass.:
41494.89
Organism:
Danio rerio
Description:
ChEMBL_116802
Residue:
369
Sequence:
MSALGESRTRLCDQFAFVSGSDSAVAQCYLAENEWDMERALNSFFEAHMDSVFDEEAEKTEVTGNKRKDDTAEASGTKKKLKTDNADCIDLTAEEPTCSITVNSKENQAENGTAKSEVEDSKLSIISWNVDGLDTLNLADRARGLCSYLALYTPDVVFLQELIPAYVQYLKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLIAQVTFSGQKLYLMTSHLESCKNQSQERTKQLRVVLQKIKEAPEDAIVIFAGDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTKANSNKTVPYVSRCRFDRIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT