Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50180241
Substrate
n/a
Meas. Tech.
ChEMBL_1583579 (CHEMBL3815666)
Ki
23±n/a nM
Citation
 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII. Bioorg Med Chem 24:3548-55 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50180241
Synonyms:
CHEMBL3813758
Type:
Small organic molecule
Emp. Form.:
C33H35N5O6S2
Mol. Mass.:
661.791
SMILES:
COc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O |c:21,t:10|
Structure:
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