Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 2
Ligand
BDBM50180660
Substrate
n/a
Meas. Tech.
ChEMBL_1584406 (CHEMBL3819949)
IC50
60±n/a nM
Citation
 Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem 59:5149-57 (2016) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2_RAT | Kcnk2 | Outward rectifying potassium channel protein TREK-1 | Potassium channel subfamily K member 2 | Stretch-activated potassium channel TREK-1 | TREK-1 K(+) channel subunit | Trek | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
PROTEIN
Mol. Mass.:
46917.42
Organism:
Rattus norvegicus
Description:
ChEMBL_116804
Residue:
426
Sequence:
MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSAKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQQIVTAINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAAEDIAVIENMK
  
Inhibitor
Name:
BDBM50180660
Synonyms:
(3S)-BUTYLPHTHALIDE
Type:
Small organic molecule
Emp. Form.:
C12H14O2
Mol. Mass.:
190.2384
SMILES:
CCCC[C@@H]1OC(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: