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Target
Dual specificity mitogen-activated protein kinase kinase 1
Ligand
BDBM50180839
Substrate
n/a
Meas. Tech.
ChEMBL_1584573 (CHEMBL3820564)
IC50
20±n/a nM
Citation
 Van Dort, ME; Hong, H; Wang, H; Nino, CA; Lombardi, RL; Blanks, AE; Galbán, S; Ross, BD Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K). J Med Chem 59:2512-22 (2016) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
MP2K1_MOUSE | Map2k1 | Mek1 | Prkmk1
Type:
PROTEIN
Mol. Mass.:
43474.56
Organism:
Mus musculus
Description:
ChEMBL_506739
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
  
Inhibitor
Name:
BDBM50180839
Synonyms:
CHEMBL1998165
Type:
Small organic molecule
Emp. Form.:
C16H15F3IN3O2
Mol. Mass.:
465.2089
SMILES:
CNCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F
Structure:
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