Reaction Details
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Ectonucleoside triphosphate diphosphohydrolase 2
Ligand
BDBM50187685
Substrate
n/a
Meas. Tech.
ChEMBL_1590660 (CHEMBL3829421)
IC50
3000±n/a nM
Citation
Fiene, A; Baqi, Y; Malik, EM; Newton, P; Li, W; Lee, SY; Hartland, EL; Müller, CE Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila. Bioorg Med Chem 24:4363-4371 (2016) [PubMed] Article More Info.:
Target
Name:
Ectonucleoside triphosphate diphosphohydrolase 2
Synonyms:
CD39L1 | ENTP2_HUMAN | ENTPD2
Type:
PROTEIN
Mol. Mass.:
53675.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453714
Residue:
495
Sequence:
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPADKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLGATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENFIKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSFLCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVSLSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMGLPVATLQQLEAAAVNVCNQTWAQLQARVPGQRARLADYCAGAMFVQQLLSRGYGFDERAFGGVIFQKKAADTAVGWALGYMLNLTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALVLLLRQVHSAKLPSTI
Inhibitor
Name:
BDBM50187685
Synonyms:
CHEMBL597418
Type:
Small organic molecule
Emp. Form.:
C28H17N2NaO5S
Mol. Mass.:
516.5
SMILES:
[Na+].Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2cc3ccccc3c3ccccc23)cc1S([O-])(=O)=O
Structure:
