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Target
NAD-dependent histone deacetylase SIR2
Ligand
BDBM27507
Substrate
n/a
Meas. Tech.
ChEMBL_1614246 (CHEMBL3856315)
IC50
<50000±n/a nM
Citation
 Kumar, A; Chauhan, S How much successful are the medicinal chemists in modulation of SIRT1: A critical review. Eur J Med Chem 119:45-69 (2016) [PubMed]  Article 
Target
Name:
NAD-dependent histone deacetylase SIR2
Synonyms:
MAR1 | SIR2 | SIR2_YEAST
Type:
PROTEIN
Mol. Mass.:
63277.80
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_942450
Residue:
562
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
  
Inhibitor
Name:
BDBM27507
Synonyms:
3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide
Type:
n/a
Emp. Form.:
C6H6N2O
Mol. Mass.:
122.1246
SMILES:
NC(=O)c1cccnc1
Structure:
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