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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50194713
Substrate
n/a
Meas. Tech.
ChEMBL_1616775 (CHEMBL3858844)
EC50
38±n/a nM
Citation
 Cid, JM; Tresadern, G; Vega, JA; de Lucas, AI; Del Cerro, A; Matesanz, E; Linares, ML; García, A; Iturrino, L; Pérez-Benito, L; Macdonald, GJ; Oehlrich, D; Lavreysen, H; Peeters, L; Ceusters, M; Ahnaou, A; Drinkenburg, W; Mackie, C; Somers, M; Trabanco, AA Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM). J Med Chem 59:8495-507 (2016) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50194713
Synonyms:
CHEMBL3892865
Type:
Small organic molecule
Emp. Form.:
C24H25F5N4
Mol. Mass.:
464.4741
SMILES:
Fc1ccc([C@@H]2CC[C@@H](CC2)NCc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(F)c1 |r,wD:8.11,5.4,(18.94,-13.23,;20.28,-12.47,;20.29,-10.92,;21.63,-10.16,;22.95,-10.95,;24.29,-10.18,;24.3,-8.64,;25.63,-7.87,;26.97,-8.65,;26.97,-10.19,;25.62,-10.96,;28.3,-7.88,;28.3,-6.35,;29.63,-5.58,;30.96,-6.35,;32.3,-5.58,;32.29,-4.03,;33.43,-2.99,;34.94,-3.31,;35.96,-2.16,;37.42,-1.67,;36.27,-.65,;32.8,-1.59,;31.27,-1.76,;30.96,-3.27,;29.63,-4.04,;28.3,-3.27,;28.3,-1.73,;26.96,-4.04,;26.96,-2.5,;22.95,-12.48,;24.29,-13.24,;21.62,-13.24,)|
Structure:
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