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Target
Renin
Ligand
BDBM50033317
Substrate
n/a
Meas. Tech.
ChEMBL_1617525 (CHEMBL3859594)
IC50
11000±n/a nM
Citation
 Imaeda, Y; Tawada, M; Suzuki, S; Tomimoto, M; Kondo, M; Tarui, N; Sanada, T; Kanagawa, R; Snell, G; Behnke, CA; Kubo, K; Kuroita, T Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg Med Chem 24:5771-5780 (2016) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50033317
Synonyms:
CHEMBL332686 | Furan-2-ylmethyl-(2-phenyl-quinazolin-4-yl)-amine
Type:
Small organic molecule
Emp. Form.:
C19H15N3O
Mol. Mass.:
301.3419
SMILES:
C(Nc1nc(nc2ccccc12)-c1ccccc1)c1ccco1
Structure:
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