Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase subunit beta-1
Ligand
BDBM50195477
Substrate
n/a
Meas. Tech.
ChEMBL_1617782 (CHEMBL3859851)
EC50
0.700000±n/a nM
Citation
 Cameron, KO; Kurumbail, RG Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators. Bioorg Med Chem Lett 26:5139-5148 (2016) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase subunit beta-1
Synonyms:
5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1
Type:
n/a
Mol. Mass.:
30380.94
Organism:
Homo sapiens (Human)
Description:
Q9Y478
Residue:
270
Sequence:
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM50195477
Synonyms:
CHEMBL3979403
Type:
Small organic molecule
Emp. Form.:
C22H16ClN3O4
Mol. Mass.:
421.833
SMILES:
COc1cc(on1)C(O)=C1C(=O)Nc2cc(Cl)c(cc12)-c1ccc2n(C)ccc2c1
Structure:
Search PDB for entries with ligand similarity: