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Target
Proteasome subunit beta type-1
Ligand
BDBM50195934
Substrate
n/a
Meas. Tech.
ChEMBL_1618120 (CHEMBL3860289)
Ki
8590±n/a nM
Citation
 Di Giovanni, C; Ettari, R; Sarno, S; Rotondo, A; Bitto, A; Squadrito, F; Altavilla, D; Schirmeister, T; Novellino, E; Grasso, S; Zappalą, M; Lavecchia, A Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening. Eur J Med Chem 121:578-591 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50195934
Synonyms:
CHEMBL3977256
Type:
Small organic molecule
Emp. Form.:
C26H34N4O7
Mol. Mass.:
514.5708
SMILES:
CC(C)CC(NC(=O)C(CO)NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(N)=O
Structure:
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