Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 16
Ligand
BDBM50029495
Substrate
n/a
Meas. Tech.
ChEMBL_1619564 (CHEMBL3861733)
IC50
110000±n/a nM
Citation
 Norman, BH; McDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem 60:66-88 (2017) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 16
Synonyms:
CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Type:
PROTEIN
Mol. Mass.:
45159.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_346884
Residue:
427
Sequence:
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
  
Inhibitor
Name:
BDBM50029495
Synonyms:
7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid | CHEMBL137953
Type:
Small organic molecule
Emp. Form.:
C19H14N4O4
Mol. Mass.:
362.3389
SMILES:
Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: