Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50198920
Substrate
n/a
Meas. Tech.
ChEMBL_1621029 (CHEMBL3863312)
IC50
<10000±n/a nM
Citation
 Abeywardane, A; Caviness, G; Choi, Y; Cogan, D; Gao, A; Goldberg, D; Heim-Riether, A; Jeanfavre, D; Klein, E; Kowalski, JA; Mao, W; Miller, C; Moss, N; Ramsden, P; Raymond, E; Skow, D; Smith-Keenan, L; Snow, RJ; Wu, F; Wu, JP; Yu, Y N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett 26:5277-5283 (2016) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Human
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50198920
Synonyms:
CHEMBL3951018
Type:
Small organic molecule
Emp. Form.:
C21H25Cl2N5O3S
Mol. Mass.:
498.426
SMILES:
CC1CCN(CC1)C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1
Structure:
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